CAS 120-82-1, chemical formula CH-1,2,4- (Cl). H302: Harmful if swallowed. There are no studies of cancer in people exposed to trichlorobenzenes. [all data], Wilhelm, Lainez, et al., 1986 Technology, Office of Data All Rights Reserved. 1,2,4-Trichlorobenzene is a highly chlorinated aromatic solvent. Condensed light ends, spent filters and filter aids, and spent desiccant wastes from the production of certain chlorinated aliphatic hydrocarbons, as defined. * Journal of Chromatography A, 1994, 672, 1-2, 141-148, https://doi.org/10.1016/0021-9673(94)80602-0 For more information, call the CDC Information Center at 1-800-232-4636. Standard enthalpies of formation and enthlpies of isomerization of trichlorobenzenes, The product He + H + is stable because in this both the electrons are close to nucleus of hydrogen and helium cation. Trichlorobenzenes have primarily been used as solvents and chemical intermediates to produce other compounds. Email: Contact CDC-INFO. For more information about the substance, you may click one of the links below to take you to the relevant section: Below are the EPA applications/systems, statutes/regulations, or other sources that track or regulate this substance. been selected on the basis of sound scientific judgment. Trichlorobenzene (TCB) may refer to any of three isomeric chlorinated derivatives of benzene with the molecular formula C6H3Cl3. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. kH = Henry's law constant for solubility in water at 298.15 K (mol/(kg*bar)) 1,2,3-Trichlorobenzene and 1,3,5 trichlorobenzene are produced in lower quantities and have fewer uses. Thermodynam., 1982, 14, 303-308. Weight of Evidence for Cancer (PDF) (14 pp, 118 K) [4] There is no regulated occupational exposure limit for chemical exposure, but the National Institute for Occupational Safety and Health recommends no greater exposure than 5 ppm, over an 8-hour workday. Mice given 1,2,4-trichlorobenzene in the food for 2 years developed cancer of the liver. [all data], Weast and Grasselli, 1989 Detecting breakdown products of trichlorobenzenes may mean that you were exposed to trichlorobenzenes or that you were exposed to other chemicals that produce the same breakdown products. Institute of Standards and Technology, nor is it intended to imply Primary and secondary antibodies, blockers and custom services. [1] Trichlorobenzenes are man-made chemical compounds that occur in three different forms. Platonov, V.A. This may be a synopsis of the full weight-of-evidence narrative. Substance Details Internal Tracking Number: 31435 Substance Type: Chemical Substance Systematic Name: Benzene, 1,2,4-trichloro- CAS Number: 120-82-1 EPA Registry Name: 1,2,4-Trichlorobenzene Molecular Weight: 181.45 Molecular Formula: C6H3Cl3 Additional Metadata All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details. Measurements of Saturated Vapor Pressure above the Liquid Phase for Isomeric Dichlorobenzenes and 1,2,4-Trichlorobenzene, Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. A dermal exposure study in mice was found inadequate for drawing conclusions as to carcinogenicity in humans. Last Updated: 05/01/1992. Please enable JavaScript and reload this page. Hydrophobic and volatile chemicals have proven to be difficult to dose in cell assays. J. Phys. Knowledgebase & FAQs; Advanced Products; Applications & Protocols Life Science Research Solutions, Products, and Resources Chromatography and Mass Spectrometry . United States Environmental Protection Agency, Some of the following links exit EPA's site, Program and regulatory information about this substance, including links to EPA applications/systems, statues/regulations, or other sources that track or regulate this substance, Standards for Owners and Operators of Hazardous Waste Treatment, Storage, and Disposal Facilities, Guidelines Establishing Test Procedures for the Analysis of Pollutants, Water Quality Guidance for the Great Lakes System, Criteria for Municipal Solid Waste Landfills, Management of Specific Hazardous Wastes and Specific Types of Hazardous Waste Management Facilities, Interim Standards for Owners & Operators of Hazardous Waste Treatment Storage & Disposal Facilities. There is virtually no information regarding health effects of trichlorobenzenes in humans. Find guidance on the latest regulations and standards in the food and beverages industry. ; 1.) Soc., 1949, 71, 7, 2575-2576, https://doi.org/10.1021/ja01175a094 #=0!w}S&!T7U/9s$5U]O~K%~ed>7ueY?*us6/Wn]/LfSG{q&^{Wz;Ec' SUvE9d"Mxx*?~:YfDK(@+hwh'3hbc^.P)d!9(@ !pqp888 j"Si)rZr L'tude de Tunnel Dmagntiseurs Le march comprend des statistiques sur la taille du march, les parts rgionales et les parts des concurrents, les segments profonds, les tendances du march, les opportunits et d'autres informations pertinentes. and Informatics, NIST / TRC Web Thermo Tables, professional edition (thermophysical and thermochemical data), Hussein Y. Afeefy, Joel F. Liebman, and Stephen E. Stein. Trichlorobenzenes are human-made compounds that occur in three different chemical forms or isomers: 1,2,3-, 1,2,4-, and 1,3,5-trichlorobenzene. TRC - Thermodynamics Research Center, NIST Boulder Laboratories, Chris Muzny director The . Here, the parent ring is styrene a benzene ring is attached to the vinyl unsaturated protons, and the chloro group is present . Browse 1,2,4-Trichlorobenzene and related products . (TRC) data available from this site, much more physical its accompanying search program. Moreover, the free concentration Get all suppliers and price by the below link: Home | B - John E. Bartmess Trichlorobenzenes have been used as solvents. The electronic configuration of HeH + is ( 1 s) 2. Journals | Data from NIST Standard Reference Database 69: The National Institute of Standards and Technology (NIST) Synthesis Reference(s): Journal of the American Chemical Society, 74, p. 3890, 1952 DOI: 10.1021/ja01135a052: Physical Properties for CAS 120-82-1: Volatilization from moist soil surfaces may be an important fate process based upon an estimated Henry's Law . errors or omissions in the Database. Go To: Top, Gas phase thermochemistry data, Condensed phase thermochemistry data, Phase change data, Reaction thermochemistry data, Gas phase ion energetics data, IR Spectrum, Mass spectrum (electron ionization), UV/Visible spectrum, References, Notes, kH(T) = kH exp(d(ln(kH))/d(1/T) ((1/T) - 1/(298.15 K))) [all data], Jones, 1960 From: Modern Inorganic Synthetic Chemistry, 2011 Related terms: Aqueous Solution View all Topics Download as PDF About this page Trichlorobenzenes Trichlorobenzenes tend to evaporate from water, but can also bind to suspended solids and sediment in water. 1,2-Dichlorobenzene, or orthodichlorobenzene (ODCB), is an organic compound with the formula C 6 H 4 Cl 2.This colourless liquid is poorly soluble in water but miscible with most organic solvents. Eng. This fact sheet answers the most frequently asked health questions (FAQs) about trichlorobenzenes. J. Chem. Chemical Structure. Chemical Structure for 1,2,4-Trichlorobenzene. 1,2,4-Trichlorobenzene, Last Updated Date : : 0956819 LAST UPDATED : 199712 DATA ITEMS CITED : 31 MOLECULAR FORMULA : C6-H3-Cl3 MOLECULAR WEIGHT : 181.44 WISWESSER LINE NOTATION : GR BG DG HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : The standard enthalpies of formation of mono-1,2,4- and 1,3,5-tri-, and 1,2,3,4- and 1,2,3,5-tetrachlorobenzenes, 0.2:1; further preferably, the molar ratio of the acid to the compound of formula III is 0.2:1. It is a derivative of benzene, consisting of two adjacent chlorine atoms.. A general reaction search . 2023 Merck KGaA, Darmstadt, Germany and/or its affiliates. (e.g., INSTITUTE OF ENERGY PROBLEMS OF CHEMICAL PHYSICS, RAS, Constant pressure heat capacity of liquid, Temperature dependence parameter for Henry's Law constant, Enthalpy of combustion of liquid at standard conditions, Enthalpy of formation of gas at standard conditions, Enthalpy of formation of liquid at standard conditions, Free energy of reaction at standard conditions, Enthalpy of reaction at standard conditions, Enthalpy of vaporization at standard conditions. Based on data from 279. Has the federal government made recommendations to protect human health? [all data], Schlosser, Marzi, et al., 2001 The isomers may also have different chemical and . Eng. P264: Wash skin thoroughly after handling. Chem. Composition(s) generated upon use Other types of composition(s) Information on Registered Substances comes from registration dossiers which have been assigned a registration number. P = vapor pressure (bar) Thank you for taking the time to confirm your preferences. Our portfolio of innovative products, services and solutions. It is mainly used as intermediate in dyes, pesticides and also as a lubricant. What Generation is Your Sterility Testing Pump? Go To: Top, Condensed phase thermochemistry data, Phase change data, Reaction thermochemistry data, Henry's Law data, Gas phase ion energetics data, IR Spectrum, Mass spectrum (electron ionization), UV/Visible spectrum, References, Notes. Even though the forms have the same molecular weight and molecular formulae, they are structurally different by the positions of the chlorine atoms attached to the benzene ring. Create the perfect solution - match and clear hexagones. The presence of trichlorobenzenes in your body means that you have been exposed to trichlorobenzenes. ALS - Hussein Y. Afeefy, Joel F. Liebman, and Stephen E. Stein Please see the following for information about Transl. 15, Am. Imaging flow cytometry makes it possible. However, NIST makes no warranties to that effect, and NIST Standard Reference Data Act. Trichlorobenzenes, tetrachlorobenzenes, and pentachlorobenzene, form is We take your privacy seriously. Merck KGaA, Darmstadt, Germany, 2014. Physical description. Chim. You can review and change the way we collect information below. 1,2,4-Trichlorobenzene for synthesis. Polymeric Microspheres and Magnetic Beads, Novabiochem Peptide and DNA Synthesis Reagents, Analytics and Sample Preparation Services, BioReliance Cell and Gene Therapy Testing Services, Calibration, Verification and Suitability Testing, Process Solutions: Portfolio Announcements, Organic Synthesis Building Blocks and Reagents for Pharma. 120-82-1. See EPAs PDF page to learn more. The isomers may also have different chemical and toxicological properties.[2][3]. on behalf of the United States of America. Database and to verify that the data contained therein have [all data], Petit and TerMinassian, 1974 the PTFE filter & XAD-2 (100/50 mg) [SKC 225-17A & SKC 226-30-4]. Stable. This page allows searching InChI=1S/C6H3Cl3/c7-4-1-2-5(8)6(9)3-4/h1-3H, National Institute of Standards and It is a colorless liquid used as a solvent for a variety of compounds and materials. Trichlorobenzenes have been detected in groundwater, drinking water, and surface water (rivers and lakes). Excess-molar volumes and heat capacities of (1,2,4-trichlorobenzene + an n-alkane) and (1-chloronaphthalene + an n-alkane), Trichlorobenzenes can be measured in blood and body fat, but the tests used are not routinely available in the doctor's office. The reaction is as follows: HeH + He + H +. 2-Bromo-1,3,4-trichlorobenzene in these sites and their terms of usage. Long term administration of 1,2,4-trichlorobenzene to rats did not affect their capacity to have normal offspring. Trust in one of the most highly published & validated portfolios of antibodies. Stull, Daniel R., Phone: 1-800-CDC-INFO 888-232-6348 (TTY) 1,2,4-Trichlorobenzene, NIOSH: Pocket Guide to Chemical Hazards - III. This table shows how each list refers to the substance. the library and To view more metadata about the specific Synonym, click on the Synonym. The bar impact test facilities include Hopkinson bar [1,2], split Hopkinson bar (Kolsky bar) [3,4,5,6,7,8,9,10], and direct impact Hopkinson bar [11,12,13].Schematics of the impact systems are illustrated in Figure 1.The Hopkinson bar measures blast/impact waves that enter through the end surface of the bar. Order 1,2,4-Trichlorobenzene as Catalog No. D0-(]PlAm*R5&{b>#7b]'Ddm\Bj. Pays-Bas, 1932, 51, 98-113. Schlosser, M.; Marzi, E.; Cottet, F.; Buker, H.H. Properties Grade anhydrous 1,2,3-Trichlorobenzene and 1,3,5-trichlorobenzene are colorless solids, but 1,2,4-trichlorobenzene is a colorless oil. uses its best efforts to deliver a high quality copy of the Optimize your QC lab workflow and ensure regulatory compliance. InChI=1S/C6H3Cl3/c7-4-1-2-5(8)6(9)3-4/h1-3H, National Institute of Standards and 1,2,4-Trichlorobenzene anhydrous, 99% Synonym (s): 1,2,4-TCB Empirical Formula (Hill Notation): C6H3Cl3 CAS Number: 120-82-1 Molecular Weight: 181.45 Beilstein: 956819 EC Number: 204-428- MDL number: MFCD00000547 PubChem Substance ID: 57648386 NACRES: NA.21 Pricing and availability is not currently available. Trichlorobenzenes have primarily been used as solvents and chemical intermediates to produce other compounds. and HTML 5 enabled browser. Your institution may already be a subscriber. Avoiding high consumption of root crops and fish living in trichlorobenzene-contaminated environments will reduce the risk of exposure. (5) 1,2,4-Trichlorobenzene occurs as a colorless liquid that is insoluble in water. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and org Spin-coating has been used extensively in the fabrication of electronic devices; however, the effects of the processing parameters have not been fully explored. Different chemical forms or isomers: 1,2,3-, 1,2,4-, and pentachlorobenzene form!, the parent ring is styrene a benzene ring is styrene a benzene is... You can review and change the way We collect information below ( bar ) Thank you for the. Reaction is as follows: HeH + He + H + answers the most published... Uses its best efforts to deliver a high quality copy of the full weight-of-evidence narrative, M. ; Marzi et... 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